Ex Utero Intrapartum Treatment (Exit) Procedure: Indications and Procedural Considerations

Authors

  • Melissa Silva

Keywords:

EXIT procedure, ex utero intrapartum treatment, cervical teratoma, congenital high airway obstruction syndrome (CHAOS)

Abstract

Problem identification

Ex Utero Intrapartum Treatment (EXIT) has become the optimal delivery strategy in fetuses with airway compromise; however, it remains an extremely rare procedure. This review aims to provide perioperative nurses with an overview of EXIT procedure to enable them to be an effective member of the multidisciplinary team.

Literature search

An electronic search of the CINAHL, Medline and Scopus databases was undertaken yielding 19 articles for inclusion in this integrative review. The papers included were case studies, case series or retrospectives and describe 42 EXIT procedures with 43 babies.

Data evaluation synthesis

The most common indication for the EXIT procedure is neck tumours, with other indications being congenital high airway obstruction syndrome (CHAOS), cardiac anomalies, extremely low birth weight (ELBW), micrognathia and congenital diaphragmatic hernia. Literature revealed 41 cases had successful establishment of an airway, with the procedure failing in two cases, both with diagnoses of CHAOS.

Implications for perioperative nursing practice or research

The role of the perioperative nurse within these cases needs to be explored further. Perioperative nurses need to have the skills and ability to participate as key members of the multidisciplinary team. This can be achieved through in-depth understanding of the topics within this review.

Author Biography

Melissa Silva

RN, MCN

References

Byun S, Lee S, Hong S, Ryu T, Kim

B, Jung J. Use of GlideScope video

laryngoscope for intubating during

ex utero intrapartum treatment in a

fetus with a giant cyst of the 4th

branchial cleft. Medicine

;95(39):1-4.

Braden A, Maani C, Nagy C.

Anesthetic management of an ex

utero intrapartum treatment

procedure: A novel balanced

approach. J Clin Anesth

;31:60-63.

Pucher B, Szydlowski J, Jonczyk-

Potoczna K, Sroczynski J. The

EXIT (ex utero intrapartum

treatment) procedure – from the

paediatric ENT perspective. Acta

Otorhinolaringol Ital 2018;38:480-

Duek I, Gil Z, Solt I. Modified ex

utero intrapartum treatment

procedure in a bicornuate uterus

breech presentation Pierre Robin

fetus with severe micrognathia and

cleft palate. Clin Case Rep

;6:2040-2044.

Matte G, Connor K, Toutenel N,

Gottlieb D, Fynn-Thompson F. A

modified EXIT-to-ECMO with

optional reservoir circuit for use

during and EXIT procedure

requiring thoracic surgery.

J Extra Corpor Technol 2016;

(1):35-38.

Gonzales S, Goudy S, Prickett K,

Ellis J. EXIT (ex utero intrapartum

treatment) in a growth restricted

fetus with tracheal atresia. Int J

Pediatr Otorhinolaryngol

;105:72-74.

Kornacki J, Szydlowski J,

Skrzyoczak J, Szczepanska M,

Rajewski M, Koziolek A et al. Use

of ex utero intrapartum treatment

in fetal neck and high airway

anomalies – report of four clinical

cases. J Matern Fetal Neonatal

Med 2019;32(5):870-874.

Rodriguez M, Moreno-Cid M,

Pascual A, Rubio A, Lopez M,

Monux A et al. Delivery strategy

for fetuses with cervical mass: The

EXIT procedure. J Obstet Gynaecol

;36(1):64-65.

Brodsky J, Irace A, Didas A,

Watters K, Estroff J, Barnewolt C

et al. Teratoma of the head and

neck: A 41-year experience. Int J

Paediatr Otorhinolaryngol

;97:66-71.

Whittemore ER, Knafl K. The

integrative review: Updated

methodology. J Adv Nurs

;52:546-553.

Hochwald O, Gil Z, Gordin A,

Winer Z, Avrahami R, Abargel E et

al. Three-step management of a

newborn with a giant, highly

vascularised, cervical teratoma: A

case report. J Med Case Rep

;13(73):1-5.

Subramanian R, Mishra P,

Subramanian R, Bansal S. Role of

anaesthesiologist in ex utero

intrapartum treatment procedure:

A case review and review of

anaesthetic management. J

Anaesthesiol Clin Pharmacol

;34(2):148-154.

Lee J, Lee M, Kim Y, Shim J, Won

H, Jeong E et al. Ex utero

intrapartum treatment procedure in

two fetuses with airway

obstruction. Obstet Gynaecol Sci

;61(3):417-420.

Shamshirsaz A, Stewart K, Erfani

H, Nassr A, Sundgren N,

Mehollin-Ray A et al. Cervical

lymphatic malformations.

Prenatal diagnosis 2019;39(4):

-292.

Cuneo B, Mitchell M, Marwan A,

Green M, Alvensleben J, Reynolds

R et al. Ex utero intrapartum

treatment to ventricular pacing: A

novel delivery strategy for complete

atrioventricular block with severe

bradycardia. Fetal Diagn Ther

;42(4):311-314.

Hung T, Huang T, Hsieh T. Ex

utero intrapartum treatment for

extremely low birthweight

neonates requiring resuscitation at

birth. Taiwan J Obstet Gynaecol

;56(4):561-563.

Said S, Qureshi M, Taggart N,

Anderson H, O’Leary P, Cetta F et

al. Innovative twostep management

strategy utilising EXIT procedure

for a fetus with hypoplastic left

heart syndrome and intact atrial

septum. Mayo Clin Proc

;94(2):356-361.

Asai H, Tachibana T, Shingu Y,

Matsui Y. Ex utero intrapartum

treatment-toextracorporeal

membrane oxygenation followed

by cardiac operation for truncus

arteriosus communis. Interact

Cardiovasc Thorac Surg

;26(2):353-354.

Agarwal A, Rosenkranz E, Yasin S,

Swaminathan S. EXIT procedure

for fetal mediastinal teratoma with

large pericardial effusion: A case

report with review of

thenliterature. J Matern Fetal

Neonatal Med 2018;31(8):1099-

Olivares E, Castellow J, Khan J,

Grasso S, Fong V. Massive fetal

cervical teratoma managed with ex

utero intrapartum treatment

(EXIT) procedure. Radiol Case Rep

;13(2):389-391.

Burwick R, Pilliod R, Dukhovny S,

Caughey A. Fetal hydrops and the

risk of severe preeclamsia. J Matern

Fetal Neonatal Med

;32(6):961-965.

Mari G, Norton M, Stone J,

Berghella V, Sciscione A, Tate D et

al. Evaluation and management of

polyhydramnios. Contemp Ob Gyn

;63(11);24-26.

Published

2020-09-01

How to Cite

Silva, M. (2020). Ex Utero Intrapartum Treatment (Exit) Procedure: Indications and Procedural Considerations. Operating Room Nurses Association of Canada Journal, 38(3), 13–24. Retrieved from https://ornacjournal.ca/index.php/ornac/article/view/12021